Childhood Cancer Survivors Have High Risk for Mortality After Cardiovascular Events
By Elana Gotkine HealthDay Reporter
WEDNESDAY, March 13, 2024 -- Childhood cancer survivors have a high risk for mortality after major cardiovascular events, according to a study published in the Feb. 27 issue of the Journal of the American College of Cardiology.
Wendy Bottinor, M.D., from Virginia Commonwealth University in Richmond, and colleagues examined the risk for mortality after a major cardiovascular event among childhood cancer survivors and siblings in the Childhood Cancer Survivor Study and participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study.
The researchers found that 1,780 survivors and 91 siblings among 25,658 childhood cancer survivors and 5,051 siblings had a cardiovascular event. Ten-year all-cause mortalities were 30, 36, and 29 percent after heart failure, coronary artery disease (CAD), and stroke among survivors versus 14, 14, and 4 percent, respectively, among siblings. Among childhood cancer survivors, all-cause mortality risks were increased after heart failure, CAD, and stroke (hazard ratios, 7.32, 5.54, and 3.57, respectively). There was an increase in CAD-specific mortality risk (hazard ratio, 3.70). Three hundred forty-five of the 5,114 CARDIA participants had a major event. At events, CARDIA participants were on average decades older (median age, 57 versus 31 years), but mortality risks were similar, with the exception of increased all-cause mortality after CAD among childhood cancer survivors (hazard ratio, 1.85).
"This study supports the concept that survivors of childhood cancer experience what appears like accelerated aging, where their overall medical profiles are similar to people who are 10 or more years older," Bottinor said in a statement.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted March 2024
Read this next
Overall Cancer Risk Not Increased for Children Born After Assisted Reproduction
FRIDAY, May 3, 2024 -- The overall risk for cancer is not increased for children born after medically assisted reproduction (MAR), according to a study published online May 2 in...
2020 Cancer Screening Rates Low at Federally Qualified Health Centers
FRIDAY, May 3, 2024 -- In 2020, there were major gaps in screening clients at federally qualified health centers (FQHCs) for various types of cancer when compared with the general...
Long-Term Study of Postmenopausal Women Does Not Support Many Preventive Therapies
THURSDAY, May 2, 2024 -- The longitudinal Women's Health Initiative trials do not support hormone therapy for cardiovascular disease prevention, calcium and vitamin D...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.